NCT05820490

ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.

Conditions

• Metabolic Health

Interventions

Type	Name	Description
OTHER	Whole Room Calorimeter	The indirect calorimetry system allows your oxygen / carbon dioxide exchange to be measured, thereby showing the number of calories burned.
OTHER	Mixed-Meal Tolerance Test (MMTT)	The MMTT is done to measure how much body handles a mixed meal.This test shake will raise blood sugar and cause the body to produce insulin.
OTHER	Core Body Temperature	Participants will be asked to swallow a core body temperature monitor prior to entering the whole room calorimeter. This monitor is used to record participants core body temperature.
OTHER	Morningness-Eveningness Questionnaire	Participants will fill out a questionnaire that asks about your preference for morning or evening.
PROCEDURE	Muscle Biopsy	Participants will have two skeletal muscle biopsies (one in the evening and one in the morning). This procedure is used to sample muscle cells from the right and left leg Vastus Lateralis (thigh) muscle.
OTHER	Serial Blood Sampling	Participants will have blood sampled every hour for 24 hours to assess changes in circulating hormones.

Timeline

• Start date: 2023-07-28
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2023-04-19
• Last updated: 2026-04-15

Locations

1 site across 1 country: United States