NCT05818657

Association of Apical Periodontitis With Chronic Kidney Disease

Prevalence of of Apical Periodontal in Patients Chronic Kidney Disease & Its Association With Markers of Kidney Disease.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 210 (actual)
• Sponsor: Postgraduate Institute of Dental Sciences Rohtak · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.

Detailed description

105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.

Conditions

• Chronic Kidney Diseases
• Periapical Lesions

Interventions

Type	Name	Description
BIOLOGICAL	levels of CKD markers, Oral health status, apical periodontitis	To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis
BIOLOGICAL	systemic inflammatory marker, Oral health status, apical periodontitis	estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis

Timeline

• Start date: 2021-12-01
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2023-04-19
• Last updated: 2023-04-19

Locations

1 site across 1 country: India