NCT05817929

Angiopoietin and Adverse Outcomes in Cardiac Surgery

Angiopoietin Dysregulation to Predict Adverse Outcomes in Cardiac Surgery: the Prospective

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac surgery and cardiopulmonary bypass can lead to systemic organ failure trough excess inflammation and endothelial injury. The angiopoietin family represented by angiopoietin 1 and 2 can reflect endothelial injury by a decrease in angiopoietin 1 and an increase in angiopoietin 2. The investigators hypothesized that angiopoietin dysregulation could reflect organ failure related to cardiac surgery. The purpose of this project is to assess the association between angiopoietin dysregulation and adverse outcomes on cardiac surgery.

Conditions

• Cardiac Surgery
• Acute Kidney Injury

Interventions

Type	Name	Description
OTHER	blood sample	5 ml blood sample will be withdrawn at the surgery start and at the surgery end

Timeline

• Start date: 2023-03-23
• Primary completion: 2026-04-01
• Completion: 2027-04-01
• First posted: 2023-04-18
• Last updated: 2025-05-25

Locations

1 site across 1 country: France