NCT05815108

Epstein Barr Virus Infection in Patients With Radiologically Isolated Syndrome

Prevalence and Prognostic Value of Epstein Barr Virus (EBV) Infection in Patients With Radiologically Isolated Syndrome (RIS)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 156 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 15 Years – 70 Years
• Healthy volunteers: —

Summary

The clinical course of RRMS patients is variable. Among RIS-Consortium international cohorts, one third of RIS patients progressed to MS at 5 years and 52.2% at 10 years. Biomarkers predictive of MS conversion are key elements to organize personalized medical care, for both follow-up and treatment strategies. EBV seems to be an interesting candidate regarding its involvement MS pathophysiology. It can be easily assess in blood sample in contrast to others prognostic biomarkers validated in RIS : oligoclonal bands and NfL levels in cerebrospinal fluid and serum. In RIS, treatment targeting EBV could significantly modify the course of the disease. The investigators aim to make the fisrt description of the EBV epidemiology (immunoglobulin (Ig)M and IgG anti-viral capsid antigen (VCA), IgG anti Epstein-Barr nuclear antigen (EBNA)) among RIS patients and to investigate a correlation between the different antibodies' titers (IgM VCA, IgG VCA, IgG EBNA) and the course of the disease (clinical conversion or evidence of disease activity (EDA)).

Conditions

• Multiple Sclerosis
• Radiologically Isolated Syndrome
• Epstein-Barr Virus

Interventions

Type	Name	Description
OTHER	NO INTERVENTION	NO INTERVENTION

Timeline

• Start date: 2023-03-15
• Primary completion: 2023-03-17
• Completion: 2023-03-17
• First posted: 2023-04-18
• Last updated: 2025-05-08

Locations

1 site across 1 country: France