Trials / Recruiting
RecruitingNCT05813418
Identification of Predictive Biomarkers for Immune-Related Adverse Events (irAEs) in Patients Undergoing Immune CheckPoint Inhibitors (ICPI) Treatment
Identification of Predictive Biomarkers for Immune-Related Adverse Events (irAEs) in Patients
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- Sponsor
- Centre Hospitalier Universitaire, Amiens · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In the last decades, cancer treatment was based on surgery, radiotherapy and chemotherapy. Recently, treatments have largely evolved, first with targeted therapies (notably tyrosin kinase inhibitors, TKI) and then with immune checkpoint inhibitors (ICPI, notably anti-CTLA-4 and anti- PD1). The last ones can induce durable anti-tumoral responses in patients, even if metastases are present. Their mechanisms of action are focused on the activation of immune system in order to eliminate the tumor. ICPI, because of their mechanisms of action, target immune tolerance key components and can induce important immune toxicities (colitis, hepatitis, dermatitis, thyroiditis ...), leading to early discontinuation of treatment, severe or chronic morbidity, and can sometimes be lethal. It is of importance to detect patient at risk of irAEs, because of the increasing use of ICPI and the long- term response capacity in treated patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | blood retriewal | blood retriewal for cytokine concentration measurement |
Timeline
- Start date
- 2021-07-02
- Primary completion
- 2025-12-01
- Completion
- 2025-12-01
- First posted
- 2023-04-14
- Last updated
- 2025-06-04
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT05813418. Inclusion in this directory is not an endorsement.