NCT05810337

Splenda: Effects on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake

The Effects of Splenda (Sucralose) on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake in Humans: a Randomised Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 18 Years – 64 Years
• Healthy volunteers: Accepted

Summary

This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.

Detailed description

Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast. Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.

Conditions

• Appetitive Behavior
• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Splenda drink	4.5g Splenda containing 1% sucralose, 95% maltodextrin, dissolved in 250ml water and consumed with a high carbohydrate breakfast.
DIETARY_SUPPLEMENT	Maltodextrin drink	4.5g maltodextrin dissolved in 250ml water and consumed with a high carbohydrate breakfast.
DIETARY_SUPPLEMENT	High carbohydrate breakfast	Meal consisting of 30g cereal with 100ml skimmed milk, 1.5 slices white toast with 12g margarine, providing 386kcal, 61.4g carbohydrate, 10.4g protein and 10.1g fat.

Timeline

• Start date: 2023-01-18
• Primary completion: 2023-02-01
• Completion: 2023-03-13
• First posted: 2023-04-12
• Last updated: 2023-04-12

Locations

1 site across 1 country: United Kingdom