NCT05804604

Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures

Serum Concentration of Bone Intake Proteins and Muscle Decay Markers as Risk Factors of Proximal Femur Fractures

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this clinical trial is to compare serum concentration of bone intake proteins \[ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)\] and muscle atrophy marker \[creatine kinase (CK-MB)\] between patients after the fracture of proximal femur and their age corresponding counterpart without the fracture. The main question it aims to answer is: • Is the higher concentration of bone intake proteins and muscle atrophy marker a predictive factor of proximal femur fracture? The part of participants (Group 1) will be hospitalized at the Department of Orthopaedics and Rehabilitation and will undergo a surgical treatment (open reduction of the fracture). The rest (Group 2) will be admitted to the Department of Internal Medicine. Participants of both Groups will have the blood sample test taken, to evaluate and compare the serum concentration of SHBG, CTX-I and CK-MB proteins.

Conditions

• Femoral Neck Fractures
• Pertrochanteric Fracture
• Bone Resorption
• Bone Loss
• Muscle Loss
• Muscle Damage

Interventions

Type	Name	Description
PROCEDURE	Surgical treatment of proximal femur fracture and blood sample test	Open reduction of femoral neck or pertrochanteric fracture with hemi/total hip arthroplasty or gamma nail. Analysis of serum concentration of: SHBG, CTX - I, CK-MB
PROCEDURE	Blood sample test	Analysis of serum concentration of: SHBG, CTX - I, CK-MB

Timeline

• Start date: 2022-05-07
• Primary completion: 2022-11-29
• Completion: 2022-11-29
• First posted: 2023-04-07
• Last updated: 2023-08-01

Locations

1 site across 1 country: Poland