NCT05801848

Diagnosis of Bone Metabolism in Patients With Inexplicable Lower Back Pain

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main goal of this study is to determine if static or dynamic \[18F\]NaF PET/CT (positron emitting tomography) can identify the source of lower backpain in at least 20% of the patients experiencing lower backpain, yet could not be diagnosed from MRI or CT scans.

Detailed description

Patients with chronic lower backpain are routinely scanned with MR and/or CT to diagnos the source of pain. Larger studies have reported that approximately 20% of patients are given a certain diagnosis from the scans and in the majority of cases the source of the pain is not determined. The use of \[18F\]NaF PET/CT to map bone perfusion and metabolism is a routine clinical scan that can potentially identify the source of lower backpain in MRI and CT negative patients. Hypothesis: That \[18F\]NaF PET/CT bone metabolism and bone perfusion images would contain information that allow the correct diagnosis in at least 20% of patients where MRI and CT images did not reveal pathology.

Conditions

• Lower Back Pain Chronic

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	[18F]NaF PET/CT scan	Patients will have their lower back scanned using \[18F\]NaF PET/CT

Timeline

• Start date: 2023-03-05
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2023-04-06
• Last updated: 2023-04-06

Locations

1 site across 1 country: Denmark