NCT05801367

Allium Sativum Oil as Alternative Non-vital Pulpotomy Medicament in Primary Teeth

Allium Sativum Oil as Alternative Non-vital Pulpotomy Medicament in Primary Teeth- A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Health Sciences Lahore · Academic / Other
• Sex: All
• Age: 4 Years – 8 Years
• Healthy volunteers: Accepted

Summary

The purpose of this randomized controlled clinical trial is to use Allium sativum oil as non-vital Pulpotomy medicament compared to Formocresol in primary teeth by evaluating its antibacterial effect against Streptococcus mutans and Lactobacillus acidophilus. It is hypothesized that there is no difference in the antibacterial effect of Allium sativum oil compared with Formocresol, when used as non-vital Pulpotomy medicaments.

Detailed description

It is a multi-arm parallel Randomized Controlled Trial in which forty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, will be selected and randomly divided into Group A (Formocresol) and Group B (Allium sativum oil). Non-vital Pulpotomy will be performed by removing the coronal necrotic pulp. Sterile paper point will be dipped in the root canals and taken to the laboratory. Cotton pellets soaked in the respective medicaments will be placed over the root canal orifices and filled temporarily. Patients will be recalled after one week. Samples will be again taken, and tooth restored. Comparison between bacterial count at baseline and after one week of treatment will be made and expressed as Colony-Forming Units/ml (CFU/ml).

Conditions

• Non-Vital Tooth

Interventions

Type	Name	Description
DRUG	Formocresol	Formocresol will be used as non-vital pulpotomy medicament (which is gold standard)
DRUG	Allium Sativum Oil	Allium sativum oil will be used as non-vital pulpotomy medicament compared with Formocresol (which is gold standard)

Timeline

• Start date: 2022-10-20
• Primary completion: 2023-02-23
• Completion: 2023-03-02
• First posted: 2023-04-06
• Last updated: 2023-04-06

Locations

1 site across 1 country: Pakistan