NCT05798286

Quantra® System With the QPlus® Cartridge in Double-lung Transplantation

Does Bedside Ultrasound Clot Elasticity Measurement Reduce Intraoperative Transfusion During Double-lung Transplantation?

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 128 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Transfusion in lung transplantation is common, and despite improved techniques and limitations in the use of mechanical circulatory support (MCS), the incidence of massive transfusion has remained stable over the years. The consequences of blood transfusion (blood cells, plasma, platelet concentrates) are deleterious for patients and increase primary graft dysfunction and mortality risk. Whole blood viscoelastic testing devices have shown its effectiveness in monitoring coagulation and fibrinolytic function during cardiac surgery, liver transplantation or trauma. So far, few delocalized biology tools have been evaluated in lung transplantation. The main objective of this study is to determine if the use of a transfusion algorithm based on whole blood viscoelastic test with Quantra® test reduce transfusion during lung transplantation.

Conditions

• Lung Diseases
• Transplant-Related Disorder

Interventions

Type	Name	Description
OTHER	Quantra	The study plans to collect 2 additional 3 mL citrate tubes of venous blood in addition to the platelet and blood counts.
OTHER	Control	The study plans to collect 1 additional 3 mL citrate tubes of venous blood in addition to the platelet and blood counts at each time.

Timeline

• Start date: 2023-05-15
• Primary completion: 2024-10-03
• Completion: 2025-10-03
• First posted: 2023-04-04
• Last updated: 2025-04-03

Locations

1 site across 1 country: France