NCT05794932

Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome

Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome: ETERecaVSPT

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Post-thrombotic syndrome (PTS) is the most frequently observed chronic complication of deep vein thrombosis (DVT), with an estimated cumulative incidence of 20-50%. Endovascular venous recanalization with angioplasty and stenting of obstructive lesions is the recommended treatment option to reduce or correct the symptoms of DVT. However, its impact on the physical capacity and breathlessness of patients has not been fully demonstrated. The heterogeneous evidences of clinical improvement is probably related to the presence or absence of collateral veins developed in these patients with proximal venous obstruction (iliac or iliofemoral with or without inferior vena cava involvement), which ensure the cardiac venous return. The aim of this study is to compare changes in maximal oxygen uptake after endovascular venous recanalization in DVT patients and to evaluate the hemodynamic, respiratory and muscular improvement induced by the restoration of venous flow in the occluded segments.

Conditions

• Post Thrombotic Syndrome
• Venous Thromboses
• Claudication, Intermittent

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Stress test	Diagnostic Test: * Maximum effort test (CPET) on a cycloergometer * Leg muscle strength assessment * Leg muscle mass, composition and water compartments (segmental bioelectrical impedance) * Spirometry, arterial blood gaz, NO/CO transfer

Timeline

• Start date: 2023-04-17
• Primary completion: 2025-05-15
• Completion: 2025-05-15
• First posted: 2023-04-03
• Last updated: 2025-05-30

Locations

1 site across 1 country: France