NCT05794776

Effect of Spinal Cord Stimulation (SCS) on Insulin Secretion in Humans

Effect of BurstDR and Tonic Spinal Cord Stimulation (SCS) on Glucose Metabolism in Patients With Neuropathic Pain

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University Hospital Tuebingen · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This trial investigates the effect of BurstDR and tonic spinal cord stimulation (SCS) on glucose metabolism and heart rate variability in patients with neuropathic pain.

Detailed description

This study investigates the effect of spinal cord stimulation (BurstDR stimulation versus tonic stimulation versus no stimulation) on glucose metabolism, insulin secretion and heart rate variability in patients with neuropathic pain. To assess insulin secretion, hyperglycaemic clamps are performed in 10 patients. Three different stimulation conditions (BurstDR, tonic and no stimulation) are tested in 10 hyperglycaemic clamps each. A total of 30 clamps are carried out.

Conditions

• Spinal Cord Stimulation
• Insulin Secretion

Interventions

Type	Name	Description
DEVICE	BurstDR stimulation	BurstDR spinal cord stimulation
DEVICE	Tonic stimulation	Tonic spinal cord stimulation
DEVICE	No stimulation	Stimulator is switched off

Timeline

• Start date: 2023-03-16
• Primary completion: 2023-09-01
• Completion: 2023-10-01
• First posted: 2023-04-03
• Last updated: 2024-05-10

Locations

1 site across 1 country: Germany