NCT05791617

PET/MR in Post Stroke Cardiac Inflammation Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 12 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with stroke have a 25x higher risk of cardiovascular complications within the first 30 days of the event compared to individuals without stroke. The mechanisms behind these complications are not well understood. Evidence suggests that inflammation plays a central role. With the present proof-of-concept prospective cohort study, the investigators aim to demonstrate that patients develop cardiac inflammation after stroke by performing positron emission tomography (PET) magnetic resonance imaging (MRI) of the heart within 15 days after stroke. As a secondary aim, the investigators will evaluate whether post-stroke cardiac inflammation persists at 3 months after stroke. The control group will be comprised of age- and sex-matched individuals without stroke.

Conditions

• Stroke
• Inflammation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	cardiac PET/MRI	Patients will undergo cardiac PET/MRI scanning at 30±5 days and at 90±5 days post-stroke.
DIAGNOSTIC_TEST	Inflammatory markers	Measurement of a panel of 92 systemic inflammatory markers on patients' blood samples at 30±5 days and at 90±5 days post-stroke
DIAGNOSTIC_TEST	Diagnostic Test: NT-proBNP	NT-proBNP is useful both in the diagnosis and prognosis of heart failure and is considered to be a gold standard biomarker in heart failure. Measurement of NT-proBNP on patients' blood samples at 30±5 days and at 90±5 days post-stroke

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-09-02
• Completion: 2025-09-02
• First posted: 2023-03-30
• Last updated: 2024-03-13

Locations

1 site across 1 country: Canada