NCT05790434

Diagnostic Criteria for Septic Arthritis

Investigation on Diagnostic Criteria for Septic Arthritis：a Multi-center Nested Case-control Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Septic arthritis (SA) is a rare but highly disabling disease. The ideal diagnosis criteria is not well established. There is an urgent need to establish golden standard for diagnosis.

Detailed description

Septic arthritis (SA) is a rare but highly disabling disease. Epidemiologic studies have documented an incidence of 0.9-1.3 per 100,000 \[1, 2\]. The treatment is challenging and the ideal diagnosis criteria is not well established. The specific tactics employed by relevant researches varied widely \[3-6\]. Patients with recurrent sepsis may require arthrodesis or amputation, which would result in severe functional loss \[2\]. Therefore, there is an urgent need to establish golden standard for diagnosis.

Conditions

• Septic Arthritis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Laboratory test	including white blood cell count, C-reactive protein, erythrocyte sedimentation rate, percent of polymorphonuclear leukocytes, albumin, and globulin
DIAGNOSTIC_TEST	History taking and physical examination	including fever, joint pain, local swelling and redness, sinus
DIAGNOSTIC_TEST	biopsy	including arthrocentesis culture，and frozen section

Timeline

• Start date: 2022-02-22
• Primary completion: 2023-05-01
• Completion: 2023-05-01
• First posted: 2023-03-30
• Last updated: 2023-03-30

Locations

2 sites across 1 country: China