NCT05786820

Impact of Pycnogenol® on Gingival Inflammation

Impact of a Dietary Supplementation With Maritime Pine Bark Extract (Pycnogenol®) on Gingival Inflammation - a Randomized Clinical Trial (PINEGIN)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Wuerzburg University Hospital · Academic / Other
• Sex: All
• Age: 35 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract (Pycnogenol®) on clinical signs of gingival inflammation in a cohort of periodontal aftercare patients

Detailed description

Polyphenols are natural compounds produced by plants that have various functions, such as defence against microbial pathogens or protection against UV light. Based on their antioxidant activity, a soothing or preventive effect of polyphenols on various inflammatory diseases has been suspected. There is evidence of an anti-inflammatory effect of polyphenols in manifest periodontitis as well as antibacterial properties of these compounds. In addition, it is discussed that dietary polyphenols intervene in mechanisms involved in the pathophysiology of arteriosclerotic changes and their progression. This randomized, double-blind, placebo-controlled 2-arm, parallel group clinical trial is designed to evaluate the impact of the regular consumption of a polyphenol-containing Maritime Pine (Pinus pinaster) bark extract (Pycnogenol®) on clinical signs of gingival inflammation in a cohort of periodontal aftercare patients

Conditions

• Periodontitis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pycnogenol	daily consumption of a pycnogenol-containing capsule
DIETARY_SUPPLEMENT	Placebo	Daily consumption of a placebo capsule

Timeline

• Start date: 2022-03-17
• Primary completion: 2024-07-20
• Completion: 2024-07-20
• First posted: 2023-03-28
• Last updated: 2024-08-09

Locations

1 site across 1 country: Germany