Trials / Completed
CompletedNCT05786755
Compositional Shift of Gut Microbiome According to the Complications in Patients With Liver Cirrhosis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 3,000 (actual)
- Sponsor
- Chuncheon Sacred Heart Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- —
Summary
Change in gut microbiome is closely associated with liver cirrhosis diseases initiation, progression, establishment, and severity. Nevertheless, compositional alterations in gut microbiome during cirrhosis development still not been evaluated, comprehensively. Here, investigators compared the gut microbial composition in cirrhosis patients to encompassing the gut microbial role in whole spectrum of disease.
Detailed description
Stool samples were collected prospectively from 240 participants (Healthy Control (HC=52) + Alcoholic Control (HC=46) + cirrhosis patients (n=142)). 16S rRNA (ribosomal ribonucleic acid) gene sequencing were performed using the MiSeq sequencer on the illumine platform and based on the phylogenetic relationship,16S-based Microbiome Taxonomic Profiling was performed to discovery gut microbial compositional shift along with cirrhosis severity progression.
Conditions
Timeline
- Start date
- 2018-08-15
- Primary completion
- 2021-06-15
- Completion
- 2021-07-10
- First posted
- 2023-03-28
- Last updated
- 2023-03-28
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT05786755. Inclusion in this directory is not an endorsement.