NCT05782829

Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)

Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.

Conditions

• Stress

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-tyrosine supplementation	L-Tyrosine supplementation before surgery for inguinal hernia under general anaesthesia
DIETARY_SUPPLEMENT	Placebo supplementation	Placebo supplementation before surgery for inguinal hernia under general anaesthesia

Timeline

• Start date: 2023-11-14
• Primary completion: 2026-04-01
• Completion: 2026-05-01
• First posted: 2023-03-24
• Last updated: 2025-12-08

Locations

1 site across 1 country: Monaco