NCT05781178

Analysis of the Aetiological Factors of Malnutrition

Analysis of the Aetiological Factors of Malnutrition: Inflammation and Oral Intake

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 271 (actual)
• Sponsor: Endocrinology and Clinical Nutrition Research Center, Spain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Disease-related malnutrition (DRM) is a frequent syndrome in clinical practice, in which the mutual relationship between disease and malnutrition is observed. Inflammation, anorexia, changes in body composition or in energy and protein requirements, contribute to the development of DRM. The Global Leadership Initiative on Malnutrition (GLIM criteria) provides a diagnostic system of malnutrition that has been accepted by the main international scientific societies in the field of clinical nutrition. The GLIM criteria proposes an algorithm that includes phenotypic criteria (weight loss, underweight and low muscle mass), with their corresponding severity thresholds, and aetiological criteria (decreased oral intake, nutrient malabsorption and the presence of an inflammatory component). The diagnosis of malnutrition is established when an aetiological and a phenotypic criterion are met. The aim of the study is to determine the diagnostic and prognostic value of aetiological factors of malnutrition based on GLIM criteria, presence and degree of inflammation and dietary intake, in patients diagnosed with DRM.

Conditions

• Disease-related Malnutrition
• Inflammation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Oral nutritional supplement rich in omega-3 and olive oil polyphenols	Nutritional intervention with an oral nutrition supplement with anti-inflammatory effect and a programme of physical exercise

Timeline

• Start date: 2023-05-02
• Primary completion: 2024-05-17
• Completion: 2024-09-11
• First posted: 2023-03-23
• Last updated: 2024-09-19

Locations

15 sites across 1 country: Spain