NCT05778968

Etco2 Levels on the End-tidal Concentration of Sevoflurane

The Effect of Different Etco2 Levels on the End-tidal Concentration of Sevoflurane in Patients Undergoing Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

he assessment of adequate levels of anaesthesia traditionally relies not only on a patient's movement but also on the hemodynamic response (or both) to a surgical stimulus

Detailed description

Currently a derivative of MAC namely, end tidal partial pressure (FET) displayed on the work station as concentration , maybe an alternative useful measure of the anaesthetic effect of an inhaled anaesthetic agent . Many pharmacological factors have been associated with alterations in MAC and Mac derivatives such as nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, and anesthetics. However, few studies have focused on physiological factors, such as hypercarbia or hypocarbia. A correlation has been found between Paco2 and Etco2 in ventilated patients with healthy lungs. Some authors have suggested that Etco2 could be considered appropriate for estimating Paco2 even in critical patients. Knowledge of the effects of Paco2 on end tidal concentration of sevoflurane among patients undergoing laparoscopic cholecystectomy may help anaesthesiologists titrate sevoflurane carefully and precisely during different mechanical ventilation settings to avoid dose-dependent hypotension, impaired cardiac contractility, and hypothermia caused by excessive anaesthetic depth of sevoflurane.

Conditions

• End-tidal Sevoflurane
• End-tidal Carbon Dioxide
• Minimum Alveolar Concentration

Interventions

Type	Name	Description
PROCEDURE	low etco2	Etco2 levels will be adjusted at levels ranging between 25 mm Hg and 30 mm Hg
PROCEDURE	normal etco2	Etco2 levels will be adjusted at levels ranging between 31 mm Hg and 40 mm Hg
PROCEDURE	high etco2	Etco2 levels will be adjusted at levels ranging between 41 mm Hg and 45 mm Hg

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-06-01
• Completion: 2024-07-29
• First posted: 2023-03-22
• Last updated: 2024-07-30

Locations

1 site across 1 country: Egypt