Trials / Completed
CompletedNCT05771805
Additional Effects of Vagus Nerve Stimulation on Motor Functions of Upper-limb in Stroke
Additional Effects of Vagus Nerve Stimulation With Task-oriented Training on Motor Functions of Upper-limb in Stroke
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (actual)
- Sponsor
- Riphah International University · Academic / Other
- Sex
- All
- Age
- 40 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke
Detailed description
Stroke is a clinical syndrome characterized by rapidly developing clinical signs of focal (or global) disturbance of cerebral function lasting more than 24 hours or leading to death with no apparent cause. Nerve stimulation paired with rehabilitation is a novel potential treatment option for people with long-term moderate-to-severe arm impairment after stroke. The study aims to determine the additional effects of vagus nerve stimulation with task-oriented training on motor functions of upper-limb in stroke. The idea of stimulating the vagus nerve to modify central brain activity has been pursued. Vagus nerve stimulation (VNS) paired with rehabilitative training enhances recovery of function in models of stroke and is currently under investigation for use in chronic stroke patients. Compared to traditional stimulation, noninvasive VNS seems to be safer and more tolerable.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Vagus nerve stimulation with task oriented training | VNS Group will receive non-invasive vagus nerve stimulation at left auricle of ear for 30 mins during the task-oriented training. Subjects will receive protocol 3 days per week for 12 weeks. |
| OTHER | Task oriented training | Task oriented group will receive task oriented training and placebo effect with vagus nerve stimulator. |
Timeline
- Start date
- 2023-03-25
- Primary completion
- 2023-07-15
- Completion
- 2023-07-15
- First posted
- 2023-03-16
- Last updated
- 2023-07-25
Locations
1 site across 1 country: Pakistan
Source: ClinicalTrials.gov record NCT05771805. Inclusion in this directory is not an endorsement.