NCT05770752

Lymphatic Function During Mechanical Ventilation

Effect of Mechanical Ventilation on Peripheral Lymphatic Function - do Elevated Intrathoracic Pressure Impact Lymphatic Flow?

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation. The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.

Detailed description

This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated. Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.

Conditions

• Lymphatic Insufficiency

Interventions

Type	Name	Description
PROCEDURE	Elevated pressure ventilation	Elevated pressure ventilation is defined as a raise in PIP and PEEP by 10 cmH2O from each patients original pressure setting, although never higher than a PIP of 30 cmH2O.

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-03-01
• Completion: 2024-10-01
• First posted: 2023-03-15
• Last updated: 2023-11-18

Locations

1 site across 1 country: Denmark