NCT05770596

Vitamin C on Acute and Chronic Post Mastectomy Pain

Impact of Perioperative Vitamin C on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 204 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This prospective randomized double-blinded controlled study will be conducted to evaluate the effect of perioperative vitamin C on acute and chronic post mastectomy pain after breast cancer surgery

Detailed description

There is cumulative evidence that postoperative pain is closely associated with subsequent persistent pain lasting months. The International Association for the Study of Pain has defined chronic postsurgical pain (CPSP) as a pain that develops after surgical intervention and persists at least 2 months.

Conditions

• Vitamin C
• Post-mastectomy Pain Syndrome

Interventions

Type	Name	Description
DRUG	vitamin C group	patients in this group will receive 2 gm vitamin C orally 1 hour before surgery and will receive 0.5 gm vitamin C per day orally for 50 days starting from the 2nd postoperative day.
OTHER	placebo group	patients in this group will receive placebo tablets with the same manner; orally 1 hour before surgery and for 50 days starting from the 2nd postoperative day.

Timeline

• Start date: 2023-04-01
• Primary completion: 2024-12-03
• Completion: 2025-12-03
• First posted: 2023-03-15
• Last updated: 2025-12-29

Locations

1 site across 1 country: Egypt