NCT05765110

SPEECH as Biomarker for Emotion, Movement and cOgnition in Parkinson's Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Accepted

Summary

With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.

Detailed description

Parkinson's disease (PD) affects mobility (motor function), thought processes (cognition) and mood (emotion). The language is one of the most complex programs in humans. It contains information about mobility, thinking and mood at the same time. These three levels of agility, thinking and mood are subject to spontaneous fluctuations and can be influenced by external stimuli such as pictures that induce emotions. In addition, these three levels are influenced on the one hand by Parkinson's disease itself, and on the other hand by its treatment with medication or with deep brain stimulation (DBS). For this reason, the investigators would like to investigate language in Parkinson's disease patients in a very detailed computerized way for motor, cognitive and emotional elements for better management of therapies. With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect fluctuations in motor, mood, and thinking in Parkinson's disease patients. Even in healthy subjects, speech changes in a situational manner, due to which the investigators will also include healthy subjects as a control group.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
OTHER	Dopaminergic OFF drug state	Experiment will be performed without dopaminergic medication
OTHER	DBS OFF state	Turning off the stimulation during experiment
OTHER	Dopaminergic ON drug state	Experiment will be performed with dopaminergic medication
OTHER	DBS ON state	Experiment will be performed with stimulation (ON condition)

Timeline

• Start date: 2023-01-03
• Primary completion: 2025-10-31
• Completion: 2026-03-31
• First posted: 2023-03-13
• Last updated: 2025-04-09

Locations

2 sites across 2 countries: Czechia, Switzerland