NCT05764850

Mechanisms of Type 1 Diabetes Endophenotypes

Mechanisms of Type 1 Diabetes Endophenotypes, by Cluster Analysis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Pediatric Clinical Research Platform · Academic / Other
• Sex: All
• Age: 0 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study consists of performing cluster analysis to decipher underlying disease mechanisms of type 1 diabetes in children and young adults. To this end, we will combine clinical, laboratory, genetic, transcriptomic, and metabolomic datasets of an extensively phenotyped cohort of children and young adults with type 1 diabetes. We will also assess the risk for cardiovascular diseases in this most vulnerable diabetes cohort.

Conditions

• Type 1 Diabetes Mellitus
• Genetic Predisposition to Disease

Interventions

Type	Name	Description
GENETIC	Genome sequencing	100 extensively phenotyped pediatric and young adult patients for genotyping, metabolomic and lipidomic analyses. Polygenic risk scores for type 1 diabetes and cardiovascular disease will be performed. For patients older than 6 years who agree to do a second visit (optional), a Mixed Meal Tolerance Test (MMTT: the gold standard for assessing beta cell function) will be done as well as transcriptomic analysis.

Timeline

• Start date: 2023-02-01
• Primary completion: 2026-02-01
• Completion: 2026-02-01
• First posted: 2023-03-13
• Last updated: 2023-03-13

Locations

1 site across 1 country: Switzerland