NCT05763966

Uppsala Psychosis Cohort

Uppsala Psychosis Cohort: a Multimodal Study in Early Stage Psychosis Patients, High Risk Individuals and Healthy Controls

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

A multimodal longitudinal study in early stage psychosis patients and individuals at high risk for psychosis. Healthy controls are included for baseline comparisons. The aim is to investigate disease mechanisms of psychotic disorders, specifically focusing on the synaptic pruning hypothesis.

Detailed description

This is a single-site observational study examining synaptic density using positron emission tomography (PET) and the radioligand \[18F\]SynVest-1 binding to the synaptic vesicle glycoprotein 2A. In addition to PET, the study includes clinical assessment, cognitive testing, multimodal magnetic resonance imaging (MRI) measures, neurophysiological measures, lumbar punction for cerebrospinal fluid (CSF) analyses, blood sampling, heart rate variability measures. Early stage psychosis patients and clinical high-risk individuals are subject to repeat assessment after 1 year (including PET), and at 3 and 5 years.

Conditions

• Schizophrenia; Psychosis

Interventions

Type	Name	Description
OTHER	No intervention	Observational study where participants are followed over time

Timeline

• Start date: 2023-04-01
• Primary completion: 2026-12-31
• Completion: 2031-12-31
• First posted: 2023-03-10
• Last updated: 2025-02-20

Locations

1 site across 1 country: Sweden