NCT05763758

Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study aims to identify spatiotemporal alterations in thalamocortical circuitry functioning in both healthy subjects and patients with chronic pain, combining multimodal neuroimaging.

Detailed description

Investigators will pursue this goal in both experimental and clinical models at two sites (Florida State U/FSU \& Mass General Hospital/MGH), implementing parallel enrollment of large and diverse samples (140 healthy participants and 60 patients with chronic low back pain/cLBP). Leveraging the fully developed multimodal neuroimaging methodology-simultaneous EEG-fMRI and combined EEG-MEG-fMRI, the investigators will investigate TC dysconnectivity (fMRI) and alpha dysrhythmia (EEG/MEG) during experimental pressure pain and chronic back pain.

Conditions

• Experimental Pain
• Low Back Pain

Interventions

Type	Name	Description
OTHER	No intervention	No intervention involved in this study

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-10-30
• Completion: 2024-12-31
• First posted: 2023-03-10
• Last updated: 2023-03-23

Locations

2 sites across 1 country: United States