NCT05763108

Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes

Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes - rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene in Patellar Instability in Children.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 250 (actual)
• Sponsor: Polish Mother Memorial Hospital Research Institute · Academic / Other
• Sex: All
• Age: 7 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.

Detailed description

After being informed about the study and potential risk all of participants were performed phisical examination and genetic test. In the study we established two groups: In first group- 50 patients with recurrent patellar dislocation and without any genetic disorders. In the second one 200 patients without recurrent patellar dislocation and genetic disorders. All pediatric patients were between 7 and 17 years old in two groups respectivly.

Conditions

• Ligament; Laxity
• Recurrent Patellar Dislocation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	genetic test	COL1A1 or COL5A1 genetic test
OTHER	Beighton joint laxity test	Based on Beighton scale.

Timeline

• Start date: 2022-04-01
• Primary completion: 2023-04-01
• Completion: 2023-12-20
• First posted: 2023-03-10
• Last updated: 2024-04-04

Locations

2 sites across 1 country: Poland