NCT05761418

Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy

Preoperative Vaginal Dinoprostone Versus Misoprostone to Decrease Bleeding During Abdominal Myomectomy

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: Female
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy

Detailed description

Background; Myomectomy is a curative interventional option for many kinds of uterine fibroids, but considerable intraoperative haemorrhage and the necessities for transfusions of blood are still the main challenge for abdomen myomectomy. Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy Subjects and methods; This was a prospective randomized double-blind controlled study that included 90 patients complaining of uterine myoma and indicated for myomectomy selected from the outpatient clinic at Beni-suef university hospital

Conditions

• Myoma;Uterus

Interventions

Type	Name	Description
DRUG	Dinoprostone	prostaglandin (PG) E2 analog
DRUG	Misoprostol	prostaglandin (PG) E1 analog

Timeline

• Start date: 2018-03-01
• Primary completion: 2023-02-15
• Completion: 2023-02-20
• First posted: 2023-03-09
• Last updated: 2023-03-09

Locations

1 site across 1 country: Egypt