NCT05760833

Ablation in Patients With HF and Symptomatic AF: PULVERISE-AF-CRT

Pulmonary Vein Isolation or Atrioventricular Node Ablation in Patients With Heart Failure and Symptomatic Atrial Fibrillation Diminishing CRT Response (PULVERISE-AF-CRT): a Randomized Study

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Pulmonary vein isolation (PVI) is currently the cornerstone non pharmacological therapy for drug-refractory atrial fibrillation (AF). Where rhythm control has been shown to be inferior as compared to rate control in older trials. New data suggest that for patients with heart failure and AF PVI may improve prognosis (mortality) as compared to medical rate or rhythm control. Whether optimal rate control as can be achieved with atrioventricular node ablation is comparable with regard to all-cause mortality of heart failure hospitalization to PVI in patients with heart failure and AF is unknown.

Conditions

• Atrial Fibrillation
• Heart Failure

Interventions

Type	Name	Description
PROCEDURE	Ablation	Ablation of either the pulmonary veins or the atrioventricular node

Timeline

• Start date: 2022-12-01
• Primary completion: 2024-04-08
• Completion: 2024-04-08
• First posted: 2023-03-08
• Last updated: 2024-05-17

Locations

1 site across 1 country: Netherlands