NCT05759780

OCT Vibrography for Biomechanical Properties of Tissues

A Study to Test the Potential of OCT Vibrography for Measuring Biomechanical Properties of Tissues

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.

Detailed description

The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo. The investigators aim to establish baseline data in healthy subjects, compare elastic moduli in different tissue types, and measure differences in elastic moduli between keratoconus and normal eyes. If successful, this project will provide useful, previously inaccessible elastic parameters and advance the investigators' understanding of the relationship between the bulk mechanical properties and the microstructure of the human tissue in vivo. This information can ultimately be used to improve the diagnosis and treatment of keratoconus, inflammatory skin diseases, and inflammatory gingiva diseases. More broadly, the technologies developed in this project will have relevance to other potential applications beyond the tissues in this research study.

Conditions

• Cornea
• Skin Diseases
• Gingival Diseases

Interventions

Type	Name	Description
DEVICE	Optical imaging of the tissues	OCT vibrography

Timeline

• Start date: 2023-08-19
• Primary completion: 2026-08-28
• Completion: 2026-08-28
• First posted: 2023-03-08
• Last updated: 2025-10-23

Locations

1 site across 1 country: United States