NCT05759481

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Milton S. Hershey Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Detailed description

Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness

Conditions

• Post-operative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	Propofol	Propofol is administered starting at surgery induction and ending at skin closure
OTHER	Placebo	Placebo is administered starting at surgery induction and ending at skin closure

Timeline

• Start date: 2024-02-01
• Primary completion: 2025-03-12
• Completion: 2025-03-12
• First posted: 2023-03-08
• Last updated: 2025-04-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study