NCT05758948

Detection of Germline and Somatic Pathogenic Variants in Patients With de Novo Metastatic Breast Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 101 (estimated)
• Sponsor: Hellenic Cooperative Oncology Group · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To determine somatic and germline pathogenic variants in patients with denovo metastatic breast cancer in order to map the molecular/genetic characteristics of DN- MBC aiming in comprehending the biology and highlighting potential novel treatment options for the disease.

Detailed description

The value of this study is based on the fact that DN-MBC is rare, seems to be different from early and relapsed breast cancer and has not been studied as distinct disease. To achieve the objective of this study blood and tissue sample from patients diagnosed with DN-MBC will be further analyzed using next generation sequencing (NGS), in order to map the molecular/genetic characteristics of DN-MBC and to detect germline and somatic pathogenic variants. All the results will be associated with the clinicopathological characteristics of the patients.

Conditions

• Metastatic Breast Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	NGS in blood and Formalin-Fixed Paraffin-Embedded (FFPE) tissue	In patients with denovo metastatic breast cancer blood and tissue sample will be collected and then further analysed using NGS in order to detect somatic and germline pathogenic variants

Timeline

• Start date: 1998-07-05
• Primary completion: 2010-10-05
• Completion: 2023-06-01
• First posted: 2023-03-08
• Last updated: 2023-04-07

Locations

1 site across 1 country: Greece