NCT05758480

Characterization of the Immunometabolic Signature in Long COVID-19.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to identify immunometabolic signatures associated with Long COVID in plasma and peripheral blood mononuclear cells (PBMC).

Detailed description

The mechanisms underlying Long COVID remain poorly understood. Among the symptoms most frequently reported by patients with long COVID, some (fatigue, neurocognitive disorders, muscular weakness) are similar to those reported by patients with innate or acquired abnormalities in energy metabolism, suggesting that metabolic changes could play a role in the disease. On the other hand, other studies have shown that COVID-19 induces an immune dysregulation that could persist after recovery. The hypothesis of this study is that there are subtle but detectable immunometabolic changes in plasma and PBMC of patients with long COVID. The identification of these specific signatures would help to better understand the physiopathology of this disease and to identify possible therapeutic strategies . The primary objective of this study is to identify immunometabolic signatures in plasma and peripheral blood mononuclear cells (PBMC) of patients with long COVID, as compared to patients who recovered from COVID-19 without prolonged symptoms.

Conditions

• Long COVID

Interventions

Type	Name	Description
BIOLOGICAL	Blood sample (at inclusion and 6 months later)	(56ml of blood, 8 tubes) 3 heparin, 1 EDTA , 2 SST, 2 CPT
OTHER	Patient questionnaires (at inclusion and 6 months later)	(4 questionnaires) Symptoms in the last week, Fatigue Impact Scale (FIS), Short-Form 36 (SF-36) and Nijmegen.

Timeline

• Start date: 2023-05-24
• Primary completion: 2025-05-07
• Completion: 2025-11-03
• First posted: 2023-03-07
• Last updated: 2026-03-09

Locations

1 site across 1 country: France