NCT05757934

Exploring the Long-term Cardiovascular Effects of Vaping

Exploring the Long-term Cardiovascular Effects of Vaping: a Longitudinal Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 172 (estimated)
• Sponsor: Sheffield Hallam University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Smoking is the "leading, preventable death-cause worldwide", being responsible for almost 700,000 deaths in the E.U. annually. Therefore, implementing successful, long-term smoking cessation strategies is a long-term priority for the NHS. Recent evidence suggests that e-cigarettes (i.e., vaping) are a successful cessation tool, with around 3.6 million users in the UK. There are concerns about long-term vaping, particularly in relation to their cardiovascular effects, as there are no relevant, longitudinal studies. Therefore, we propose a 38-month, four-group longitudinal study exploring the cardiovascular physiological effects of the use of e-cigarettes over a two-year period, informing policy makers and e-cigarette users (vapers). Our study was developed with the support of vapers. The main research question is whether there are any differences in cardiovascular physiology between vapers, who are ex-smokers (Group A), vapers with no previous smoking experience (Group B), dual users (i.e., those who vape and smoke (Group C) and ex-smokers who don't vape (Group D). Two-hundred participants from Sheffield and Leeds will be invited on five occasions (baseline, as well as 6-,12-,18- and 24-months post-baseline). We will assess macrovascular and lung function, cardiovascular disease risk (through questionnaires and blood biomarkers), vaping and smoking dependence, smoking and and vaping history among others.

Conditions

• Cardiovascular Diseases

Timeline

• Start date: 2023-04-16
• Primary completion: 2026-01-30
• Completion: 2026-06-30
• First posted: 2023-03-07
• Last updated: 2024-10-10

Locations

1 site across 1 country: United Kingdom