NCT05754125

In Vivo and in Vitro Anabolic Potential of Essential Amino Acids Following Resistance Exercise

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study seeks to investigate the anabolic potential of a dileucine-enriched essential amino acid (EAA) formulation compared with a branched chain amino acid (BCAA) alternative and a collagen beverage on muscle protein anabolism and catabolism following a bout of resistance exercise training. To do this, investigators will employ a novel 'breath test' method developed in our laboratory as well as blood and urine sampling. The results of this study will allow us to better understand the anabolic potential of dileucine which could have implications for people engaging in regular resistance training (such as athletes) as well as people that need to preserve muscle mass (older people who are susceptible to anabolic resistance and sarcopenia, or muscle wasting).

Conditions

• Interventional

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Di-Leucine Supplement	Participants will consume a amino acid supplement containing Di-Leucine following resistance exercise and their whole body anabolism will be determined over the subsequent 6 hours
DIETARY_SUPPLEMENT	BCAA Supplement	Participants will consume a amino acid supplement containing branched chain amino acids (BCAA) following resistance exercise and their whole body anabolism will be determined over the subsequent hours
DIETARY_SUPPLEMENT	Collagen Supplement	Participants will consume a amino acid supplement containing Collagen protein following resistance exercise and their whole body anabolism will be determined over the subsequent hours

Timeline

• Start date: 2023-01-21
• Primary completion: 2023-07-30
• Completion: 2024-01-30
• First posted: 2023-03-03
• Last updated: 2023-11-09

Locations

1 site across 1 country: Canada