NCT05752929

Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients

Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients in an Institution in Bogotá, Colombia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 116 (actual)
• Sponsor: Hospital Universitario Clinica San Rafael · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Hyperglycemia in the hospital is associated with multiple adverse outcomes. Previously, the mobile insulin scheme was used for its control. However, in the last decade, several studies have shown that the insulin basal-bolus (basal plus) regimen is associated with better glycemic control and a lower risk of hypoglycemia.

Detailed description

Introduction: Hyperglycemia in the hospital is associated with multiple adverse outcomes. Previously, the mobile insulin scheme was used for its control. However, in the last decade, several studies have shown that the insulin basal-bolus (basal plus) regimen is associated with better glycemic control and a lower risk of hypoglycemia. Objective: To compare the sensitive scheme of Umpierrez and the correction factor suggested by Davidson (1700/total dose of insulin) for the correction of hyperglycemia in patients with type 1 diabetes mellitus. Methods: Unblinded, randomized, controlled clinical trial in patients with hyperglycemia and type 2 diabetes mellitus hospitalized at a hospital in Bogotá, Colombia, between 2016 and 2018. A probabilistic sampling with randomly permuted blocks was performed. The Umpierrez sensitive correction scheme and the Davidson correction factor were compared by evaluating glycemic control at 2 and 5 hours, and the presence of hypoglycemia.

Conditions

• Diabete Type 2
• Hyperglycemia

Interventions

Type	Name	Description
DRUG	Insulin	correction scheme with Rapid Acting Insulin Analogs according with the Umpierrez sensitive correction scheme
DRUG	insulin	correction scheme with Rapid Acting Insulin Analogs according with the Davidson correction scheme

Timeline

• Start date: 2016-01-01
• Primary completion: 2018-12-31
• Completion: 2019-12-31
• First posted: 2023-03-03
• Last updated: 2023-03-03