NCT05752409

Comparison of Esketamine-Propofol and Fentanyl-Propofol

Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Eye & ENT Hospital of Fudan University · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Propofol is widely used as an induction agent during general anesthesia. The prevalent induction dose may be associated with unacceptable cardiovascular instability, especially in elderly patients.The combination of ketamine and propofol has been shown to balance the cardiodepressant effects. Esketamine is dextrorotatory structure of ketamine but with stronger analgesic effects and fewer adverse events.However, there have been no previous published reports on the use of esketamine combined with propofol during induction. The main aim of this study was to investigate the haemodynamic effects of esketamine with propofol for the elderly during induction with LMA( laryngeal mask airway) insertion.

Detailed description

Propofol is widely used as an induction agent during general anesthesia. The prevalent induction dose may be associated with unacceptable cardiovascular instability, especially in elderly patients. 1.7(0.6) mg.kg-1 adjusted dosed propofol demonstrated by a large multicenter cohort is suitable to advanced patients over aged 65. Ketamine increases heart rate and arterial blood pressure by its activation of the sympathetic nervous system. When it is used with propofol for induction of general anesthesia, the cardiostimulating effects of ketamine balance the cardiodepressant effects of propofol. Esketamine is dextrorotatory structure of ketamine but with stronger analgesic effects and fewer adverse events. A previous study has shown that the use of ketamine before induction with propofol preserves haemodynamic stability during LMA insertion. However, there have been no previous published reports on the use of esketamine combined with propofol in elderly patients for induction. The main aim of this study was to investigate the haemodynamic effects of esketamine with propofol during induction with LMA insertion. The secondary aim was to investigate whether the administration of esketamine in induction would delay the emergence of anesthesia.

Conditions

• Hemodynamics

Interventions

Type	Name	Description
DRUG	The median dose of esketamine	1mg•kg-1propofol and 0.5 mg•kg-1esketamine for general anesthesia induction.
DRUG	The high dose of esketamine	1mg•kg-1propofol and 0.75 mg•kg-1esketamine for general anesthesia induction.
DRUG	Propofol	2mg•kg-1propofol for general anesthesia induction.

Timeline

• Start date: 2021-10-08
• Primary completion: 2023-11-30
• Completion: 2023-12-31
• First posted: 2023-03-02
• Last updated: 2023-08-15

Locations

1 site across 1 country: China