NCT05750940

Oxidative Skeletal Muscle Metabolism in Chronic Heart Failure Patients With and Without Iron Deficiency

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Observational study using in vivo noninvasive 31 phosphor magnetic resonance spectroscopy (31P MRS) to quantify the effect of iron deficiency (ID) on skeletal oxidative metabolism in patients with chronic heart failure (HF).

Detailed description

Iron Deficiency (ID) is a comorbidity in heart failure (HF) patients with high prevalence and severe clinical consequences. Multiple studies have shown that ID in HF patients impairs exercise capacity, quality of life and outcome. It is currently unknown whether these detrimental consequences of ID are due to cardiovascular or hematologic effects, or deteriorated peripheral muscle metabolism and function. This study was designed to quantify the effect of ID on skeletal oxidative metabolism in patients with chronic HF.

Conditions

• HF - Heart Failure
• Iron-deficiency

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	31Phosphor Magnetic Resonance Spectroscopy	Measurement of skeletal oxidative metabolism with 31phosphor magnetic resonance spectroscopy

Timeline

• Start date: 2021-10-05
• Primary completion: 2023-04-01
• Completion: 2023-05-01
• First posted: 2023-03-02
• Last updated: 2023-03-02

Locations

1 site across 1 country: Netherlands