NCT05749393

Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm

Effect of Heparinization on Intracranial Aneurysm

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: The First Affiliated Hospital with Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms. Participants will be randomized to different intraoperative heparinization regimens: (i) 50 U/kg intravenous (IV) at 1-h intervals reduced by half to a minimum of 1000 u/h; (ii) 70 U/kg IV at 1-h intervals reduced by half to a minimum of 1000 u/h. MRI will be performed within 72 h after surgery, and the DWI sequence of MRI will be analyzed. If there is a comparison group: Researchers will compare different intraoperative heparinization protocol groups to see which dose of intraoperative heparin has the best prognosis for use.

Conditions

• Intracranial Aneurysm

Interventions

Type	Name	Description
DRUG	Heparin sodium	Intravenous heparin was administered during intracranial aneurysm embolization with a guide catheter and discontinued at the end of the procedure.

Timeline

• Start date: 2023-04-30
• Primary completion: 2024-03-31
• Completion: 2024-04-01
• First posted: 2023-03-01
• Last updated: 2023-12-22

Locations

1 site across 1 country: China