NCT05747547

Retinal Vascular Changes in Patients After Coronavirus Disease 2019 (COVID-19)

Retinal Vascular Changes in Patients After Coronavirus Disease 2019 (COVID-19) Based on Retinal Oximetry

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: University Hospital Olomouc · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study examines changes in retinal oximetry in patients after COVID-19 disease. It aims to analyze and quantify possible retinal microvascular abnormalities that may result from possible post-inflammatory damage to the endothelium of the vessels associated with COVID-19 disease. Retinal vascular involvement may indicate similar changes in the vascular system in other organs.

Detailed description

The retinal blood vessels are the only blood vessels in the body that can be observed directly. Patients with COVID-19 pneumonia have been shown to have reduced macular vessel density in the foveal region. As a result, some layers of the retina atrophy, reducing oxygen consumption by the retina. Based on this, it is expected that patients after COVID-19 pneumonia, or after a more severe course of the disease, will have normal arterial retinal oxygen saturation but higher venous retinal oxygen saturation and lower arterio-venous difference than patients after mild disease.

Conditions

• COVID-19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Central visual acuity	Measurement of central visual acuity using ETDRS (Early Treatment Diabetic Retinopathy Study) optotypes or Snellen optotype chart.
DIAGNOSTIC_TEST	Intraocular pressure measurement	Measurement of intraocular pressure using non-contact Canon TX-20P tonometer.
DIAGNOSTIC_TEST	Slit lamp examination	Slit lamp examination of the anterior and posterior segment of the eye after pharmacological dilation of the pupil using application of short-time mydriatics (1% tropicamide and 10% phenylephrine).
DIAGNOSTIC_TEST	Retinal oximetry	Performing of retinal oximetry with an Oxymap T1 instrument (Oxymap ehf.) paired with a Topcon TRC-50DX retinal camera.
DIAGNOSTIC_TEST	Optical coherence tomography and angiography	Performing of optical coherence tomography and angiography with the Spectralis Optical Coherence Tomography Plus (Heidelberg Engineering).

Timeline

• Start date: 2022-08-01
• Primary completion: 2023-05-01
• Completion: 2024-10-01
• First posted: 2023-02-28
• Last updated: 2025-05-29

Locations

1 site across 1 country: Czechia