NCT05747365

Role of Endocrine Disruptors in Thyroid Cancer

Cross-sectional Case-control Study on the Role of Endocrine Disruptors in Thyroid Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 222 (estimated)
• Sponsor: Istituto Auxologico Italiano · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS). The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).

Conditions

• Endocrine Disruptor Chemicals
• Thyroid Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood and urine diagnostic evaluation	Blood and urine samples will be obtained from both case and control groups in order to evaluate EDCs concentrations

Timeline

• Start date: 2022-07-12
• Primary completion: 2023-04-30
• Completion: 2025-07-31
• First posted: 2023-02-28
• Last updated: 2024-04-16

Locations

1 site across 1 country: Italy