NCT05746520

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) - Atrium Health

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 268 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Detailed description

This is a single center, randomized controlled trial to determine if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Conditions

• Appendicitis Surgery

Interventions

Type	Name	Description
OTHER	Antibiotic	Type of antibiotic is per clinical judgement with the duration being the experimental aspect of this study.

Timeline

• Start date: 2023-03-02
• Primary completion: 2025-06-18
• Completion: 2025-07-21
• First posted: 2023-02-27
• Last updated: 2025-11-03

Locations

1 site across 1 country: United States