NCT05746377

Metoclopramide in Upper Gastrointestinal Bleed

Premedication With Metoclopramide in Upper Gastrointestinal Bleeds a Prospective Double Blinded Single Center Randomized Control Trial in a Small Community Hospital

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Mercy Health System · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to test if metoclopramide can improve effectiveness of endoscopic intervention in upper gastrointestinal (GI) bleeds. The main questions the investigators hope to answer is Does metoclopramide lessen the need for repeat endoscopy, interventional radiology intervention or surgery in cases of upper GI bleed? Does metoclopramide improve visibility of the GI walls in cases of upper GI bleed?

Detailed description

The purpose of the study is to see if giving metoclopramide prior to an endoscopy in cases of upper GI bleed can decrease the need for repeat endoscopy due to poor visibility. Metoclopramide stimulates stomach and intestine activity. It is used to treat nausea, vomiting and slow gut movement. The investigators are testing if metoclopramide's effect on stimulating stomach activity can lead to more effective emptying of blood from the stomach and upper intestines in upper GI bleeding so physicians conducting endoscopies can easily see the stomach and intestinal wall and treat the source of bleeding.

Conditions

• Upper GI Bleeding
• Bleeds Gastric
• Bleed Ulcer
• Hemorrhage Gastric
• Hemorrhage; Ulcer

Interventions

Type	Name	Description
DRUG	Metoclopramide 10mg	IV Metoclopramide
DRUG	Saline	Placebo

Timeline

• Start date: 2023-05-20
• Primary completion: 2024-02-01
• Completion: 2024-06-01
• First posted: 2023-02-27
• Last updated: 2023-07-11

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study