NCT05742945

Can ILR Reduce the Risk of Arm Lymphedema?

Can Immediate Lymphatic Reconstruction With Lymphatico-Venous Anastomosis Reduce the Occurrence of Arm Lymphedema in Breast Cancer Patients After Axillary Lymph Node Dissection? A Prospective Randomized Controlled Trial.

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Breast cancer-related lymphedema (BCRL) is a debilitating, usually lifelong burden for breast cancer survivors. For the breast cancer patients receiving axillary lymph node dissection (ALND), the likelihood of BCRL is about 20%. Lymphatico-venous anastomosis (LVA) has been accepted as a method of treating extremity lymphedema. A few studies have mentioned the prophylactic effect of LVA on BCRL. However, there is still lack of a large-scale randomized controlled trial to corroborate its efficacy. Therefore, the goal of this study is to conduct a prospective randomized controlled trial to evaluate if immediate lymphatic reconstruction (ILR) with LVA could have a clinically significant effect on the reduction of BCRL occurrence.

Conditions

• Breast Cancer Lymphedema

Interventions

Type	Name	Description
PROCEDURE	Immediate lymphatic reconstruction	Breast cancer patients receive axillary lymph node dissection and immediate lymphatic reconstruction

Timeline

• Start date: 2023-02-14
• Primary completion: 2028-08-01
• Completion: 2028-08-01
• First posted: 2023-02-24
• Last updated: 2024-03-19

Locations

1 site across 1 country: Taiwan