NCT05738460

Effects of IAP-EOGBSD on Offspring's Gut Microbiome and Immunity.

The Effects of Intrapartum Antibiotic Prophylaxis to Prevent Group B Streptococcal Early-onset Disease on Intestinal Microbiome and Immunity of Offspring

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: Zhujiang Hospital · Academic / Other
• Sex: All
• Age: 37 Weeks – 41 Weeks
• Healthy volunteers: —

Summary

This study is planned to be recruited in two hospitals in South China, Zhujiang Hospital of Southern Medical University and Zhongshan Boai Hospital Recruit participants, plan to recruit obstetrics and child health departments in study hospitals, meet inclusion and discharge criteria 1\~3 infants, a total of 360, recruited by Pearl River Hospital of Southern Medical University and Zhongshan Boai Hospital 180 people each.

Detailed description

This is a case-control study. By collecting fecal samples of infants and young children in the observation group and control group at different time points (0\~1 years old, 1\~2 years old, 2\~3 years old), the intestinal flora of infants and young children was detected by 16S rDNA sequencing, and fecal calprotectin (CP) and secretory IgA (SIgA) were detected by ELISA. To study the effects of exposure factors on intestinal flora and immunity in offspring.

Conditions

• Healthy
• Metabolism
• Microbiome

Interventions

Type	Name	Description
DRUG	antibiotics	Reproductive tract GBS colonization group of mothers during pregnancy，Use of antibiotics

Timeline

• Start date: 2022-02-23
• Primary completion: 2023-06-30
• Completion: 2023-06-30
• First posted: 2023-02-22
• Last updated: 2023-02-22

Locations

1 site across 1 country: China