NCT05736237

Identification and Verification of Candidate Genes Responsible for Optic Disc Drusen Development

Identification and Verification of Candidate Genes Responsible for Optic Disc Drusen

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Copenhagen University Hospital at Herlev · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about the genetic background for the development of optic disc drusen. The main question is: • Can one or more candidate genes be found? Participants will have a blood sample taken and answer a questionnaire.

Detailed description

The study is an international collaboration between University of Utah, University of Sydney, University of Valladolid, and University of Copenhagen. Patients with Optic disc drusen from 15 known optic disc drusen-families from different countries (USA, Australia, Spain and Denmark) are participating in this study. Blood samples are drawn from each patient and their affected and unaffected family members, and DNA will be extracted. The investigators will do an Optical coherence tomography-scan (according to ODDS Consortium guidelines), and the participant will be asked to fill out the Visual Function Questionnaire (VFQ-25) including four additional questions about optic disc drusen. The etiology of optic disc drusen will be analyzed with a Whole Exome Sequencing (WES), with the use of Next Generation Sequencing (NGS). Prior to WES, all participants will receive genetic counseling by a consultant to ensure awareness of possible secondary genetic findings.

Conditions

• Optic Disk Drusen

Interventions

Type	Name	Description
GENETIC	Whole exome sequencing	With Next Generation Sequenzing

Timeline

• Start date: 2023-05-01
• Primary completion: 2024-05-31
• Completion: 2024-05-31
• First posted: 2023-02-21
• Last updated: 2024-08-02

Locations

1 site across 1 country: Denmark