NCT05735912

EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT)

Endoscopic Ultrasound-guided RAdiofrequency Ablation Versus Surgical Resection for the Treatment of Pancreatic INsulinoma: a Multicenter Randomized Controlled Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Azienda Ospedaliera Universitaria Integrata Verona · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this muticentre randomized controlled trial is to compare endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with surgery for treatment of pancreatic insulinoma. The main questions it aims to answer are: 1) What is the safest treatment? 2) Is efficacy comparable? Patients will be randomized to undergo EUS-RFA or surgical resection. Researchers will compare the rate of adverse events and the clinical efficacy after the two treatments to see if EUS-RFA result safer and effective compare with surgery.

Conditions

• Pancreatic Insulinoma

Interventions

Type	Name	Description
PROCEDURE	Endoscopic ultrasound-guided radio frequency ablation	Radiofrequency ablation performed under endoscopic ultrasound guidance of pancreatic insulinoma
PROCEDURE	Surgery	Surgical resection of pancreatic insulinoma

Timeline

• Start date: 2023-03-01
• Primary completion: 2028-10-31
• Completion: 2028-10-31
• First posted: 2023-02-21
• Last updated: 2026-01-13

Locations

1 site across 1 country: Italy