NCT05730140

The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome

Association Between Whole Exon Sequencing and Arterial Stiffness in Patients With Intraoperative Hypotension)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: —

Summary

The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

Detailed description

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes. We will enroll patients older than 20 years old and undergo elective general anesthesia. Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor. After completing surgery, we will follow the patients' all postoperative major organ function. We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Conditions

• the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect

Interventions

Type	Name	Description
OTHER	this study did not involve interventions; it only observational study	this study did not involve interventions. This study is an observational study for elucidating the intraoperative blood pressure changes, artierial stiffness, and whole exome genome

Timeline

• Start date: 2023-02-10
• Primary completion: 2028-12-31
• Completion: 2030-12-31
• First posted: 2023-02-15
• Last updated: 2023-02-15