NCT05729269

Characterization of Gut Microbiota in Chronic Liver Disease With Decreased Muscle Mass

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 283 (actual)
• Sponsor: Chuncheon Sacred Heart Hospital · Academic / Other
• Sex: All
• Age: 24 Years – 82 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to confirm the presence of specific gut microbiota observed in patients with sarcopenia among patients who agreed to analyze gut microbiota through stool among multi-center chronic liver disease cohort patients.

Detailed description

The effect of gut microbiota on liver disease is also well known and many studies are ongoing. A recently published study summarized the differences in the composition of gut microbiota in non-alcoholic fatty liver, steatohepatitis, and cirrhosis, and reported that metabolites from the changed gut microbiota may be a factor influencing non-alcoholic fatty liver disease (NAFLD) progression. These changes in gut microbiota composition have been reported to affect clinical outcomes in patients by causing an increase in endotoxin, a change in bile acid metabolism, and a decrease in short chain fatty acid. In particular, the reduction of short chain fatty acid is known to be associated with the occurrence of sarcopenia. Sarcopenia, which is common in patients with cirrhosis, which is a representative chronic liver disease, is well known as a poor prognostic factor for patients. Therefore, this study aims to analyze the distribution of gut microbiota observed in patients with sarcopenia through the gut microbiota investigated in the chronic liver disease cohort patient group and the characteristics of the distribution of gut microbiota for each disease corresponding to chronic liver disease.

Conditions

• Gastrointestinal Microbiome
• Sarcopenia
• Liver Disease Chronic

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Sarcopenia_CT	measurement of skeletal muscle through abdominal computed tomography

Timeline

• Start date: 2017-03-22
• Primary completion: 2019-04-30
• Completion: 2021-12-31
• First posted: 2023-02-15
• Last updated: 2023-02-15

Locations

1 site across 1 country: South Korea