NCT05728710

Outcomes of Perforation After Colorectal Endoscopic Submucosal Dissection

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 350 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Endoscopic resection of superficial colorectal neoplasms decrease risk of colorectal cancer. En bloc resection is necessary for large superficial lesions with risk of superficial submucosal cancer and is advised if feasible for all lesions. Endoscopic submucosal dissection (ESD) allows en bloc resection of large superficial colorectal neoplasms, increasing curative resection rate and decreasing local recurrence risk. However, the risk of perprocedural or delayed perforation is higher compared to wild field piece meal endoscopic mucosal resection. Endoscoping clipping and closing methods mostly allow conservative treatment, but some case still necessitate surgery. The aim of our study is to describe and ananalyse outcomes after perprocedural or delayed perforation in all patients undergoing ESD and analyse the need for surgical intervention.

Conditions

• Colorectal Neoplasms
• Perforation of Rectum
• Perforation Colon

Interventions

Type	Name	Description
PROCEDURE	Endoscopic submucosal dissection	standard ESD performed and complicated with a perprocedural or delayed perforation

Timeline

• Start date: 2019-09-01
• Primary completion: 2023-03-31
• Completion: 2023-04-01
• First posted: 2023-02-15
• Last updated: 2023-02-15

Locations

13 sites across 2 countries: Belgium, France